Opioid use disorder deaths by sex in United States of America

United States of America: Opioid use disorder deaths by sex was 24,856 deaths in 2021. ◆ Volatile

Latest (2021)
24,856 deaths
Change on year
up 17.3%
World rank
1st
of 194 countries
All-time high
24,856 deaths
in 2021
All-time low
2,838 deaths
in 2000
Years of data
22
2000–2021

Opioid use disorder deaths by sex in United States of America, 2000–2021

5.0k10.0k15.0k20.0k25.0k2000201020212000: 2.8k deaths2001: 3.3k deaths2002: 4.3k deaths2003: 5.0k deaths2004: 5.6k deaths2005: 6.3k deaths2006: 7.3k deaths2007: 7.9k deaths2008: 8.2k deaths2009: 8.7k deaths2010: 9.3k deaths2011: 10.2k deaths2012: 10.3k deaths2013: 11.0k deaths2014: 11.9k deaths2015: 13.0k deaths2016: 15.1k deaths2017: 16.6k deaths2018: 15.9k deaths2019: 16.3k deaths2020: 21.2k deaths2021: 24.9k deaths

Source: World Health Organization (2024) – with major processing by Our World in Data. Measured in deaths.

Analysis

The most recent figure for opioid use disorder deaths by sex in United States of America is 24,856 deaths, measured in 2021. That is the highest value across all 22 years on record.

That represents a change of up 17.3% on the previous year and up 144.7% over ten years.

Over the whole period, opioid use disorder deaths by sex in United States of America peaked at 24,856 deaths in 2021 and was at its lowest, 2,838 deaths, in 2000.

United States of America ranks 1st of 194 countries on this measure, in the top 10%.

The series is highly variable year to year, so single readings are best treated with caution.

Opioid use disorder deaths by sex in United States of America, year by year

Annual values for Opioid use disorder deaths by sex in United States of America, 2000 to 2021.
Year deaths Change
2000 2,838 deaths
2001 3,251 deaths +14.5%
2002 4,287 deaths +31.9%
2003 5,000 deaths +16.6%
2004 5,643 deaths +12.9%
2005 6,327 deaths +12.1%
2006 7,329 deaths +15.8%
2007 7,949 deaths +8.5%
2008 8,225 deaths +3.5%
2009 8,686 deaths +5.6%
2010 9,283 deaths +6.9%
2011 10,160 deaths +9.4%
2012 10,297 deaths +1.4%
2013 10,973 deaths +6.6%
2014 11,889 deaths +8.3%
2015 12,994 deaths +9.3%
2016 15,106 deaths +16.3%
2017 16,631 deaths +10.1%
2018 15,874 deaths -4.6%
2019 16,298 deaths +2.7%
2020 21,184 deaths +30.0%
2021 24,856 deaths +17.3%

Averages by decade

DecadeAverage LowestHighest Years
2000s 5,953 deaths 2,838 deaths 8,686 deaths 10
2010s 12,951 deaths 9,283 deaths 16,631 deaths 10
2020s 23,020 deaths 21,184 deaths 24,856 deaths 2

Countries ranked near United States of America

  1. 2 India 1,811 deaths compare
  2. 3 Canada 1,428 deaths compare
  3. 4 United Kingdom of Great Britain and Northern Ireland 1,192 deaths compare

See the full ranking of 194 places →

More health data for United States of America

All data for United States of America →

Frequently asked questions

What is opioid use disorder deaths by sex in United States of America?
Opioid use disorder deaths by sex in United States of America was 24,856 deaths in 2021, according to World Health Organization (2024) – with major processing by Our World in Data.
What is the highest opioid use disorder deaths by sex recorded in United States of America?
The highest recorded value was 24,856 deaths in 2021.
What is the lowest opioid use disorder deaths by sex recorded in United States of America?
The lowest recorded value was 2,838 deaths in 2000.
How does United States of America rank for opioid use disorder deaths by sex?
United States of America ranks 1st out of 194 countries with data for 2021.
Is opioid use disorder deaths by sex rising or falling in United States of America?
Over the last ten years it is up 144.7%. The long-run trend across the full record is volatile.
Where does this United States of America data come from?
The figures come from World Health Organization (2024) – with major processing by Our World in Data, published as part of Opioid use disorder deaths by sex. Statizoid updates them automatically from the source API.

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Opioid use disorder deaths by sex in United States of America. Statizoid, drawing on World Health Organization (2024) – with major processing by Our World in Data. Retrieved 05 September 2026, from https://health.statizoid.com/stat/deaths-opioid-overdoses-by-sex/united-states/

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About this data

Indicator
Opioid use disorder deaths by sex
Unit
deaths
Source
World Health Organization (2024) – with major processing by Our World in Data
Licence
CC BY 4.0 (Our World in Data)
Coverage
194 places, 4,268 data points, 2000–2021
Last refreshed

Estimated number of deaths from opioid use disorders in females.